Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Dec;13(6):563-6.
doi: 10.1016/j.jaapos.2009.09.019.

Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus

Tara H Cronin  1 , Richard W Hertle, Hiroshi Ishikawa, Joel S Schuman
Affiliations

Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus

Tara H Cronin et al. J AAPOS. 2009 Dec.

Abstract

Purpose: To evaluate the feasibility of spectral domain optical coherence tomography (SD-OCT) macular scanning as a means of studying the afferent visual system in nystagmus patients.

Methods: Nystagmus patients who underwent SD-OCT, clinical evaluation, and eye movement recordings were recruited for this prospective, single-center, noncomparative study. Three SD-OCT macular three-dimensional cube scans per eye (200 x 200 x 1024 samplings in a 6 x 6 mm region) were obtained for qualitative retinal morphology analysis.

Results: Nineteen patients (6-68 years; average, 19 years) were analyzed. Of these, 17 patients had infantile nystagmus syndrome, and 2 had fusion maldevelopment nystagmus; 17 patients (89%) had associated sensory system abnormalities, including 9 (47%) with albinism. Macular images were successfully obtained in all but 1 patient (95%). Of the 8 successfully imaged oculocutaneous patients, 7 patients demonstrated "fovea plana," and all demonstrated abnormal morphology.

Conclusion: SD-OCT reliably provides detailed structural imaging of the fovea in nystagmus patients.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Spectral domain optical coherence tomography image demonstrating (A) foveal plana in oculocutaneous albinism (Patient 4), (B) slight foveal differentiation in oculocutaneous albinism (Patient 6), and (C) normal foveal morphology in a patient with infantile nystagmus syndrome and no identifiable sensory abnormality (Patient 3).
See this image and copyright information in PMC

References

    1. Wojtkowski M, Bajraszewski T, Gorczynska I, et al. Ophthalmic imaging by spectral optical coherence tomography. Am J Ophthalmol. 2004;138:412–19. - PubMed
    1. Srinivasan VJ, Wojtkowski M, Witkin AJ, et al. High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology. 2006;113:2054.e1–14. - PMC - PubMed
    1. Jiao S, Knighton RW, Huang X, Gregori G, Puliafito CA. Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography. Optics Express. 2005;13:444–52. - PubMed
    1. Wojtkowski M, Srinivasan VJ, Fujimoto JG, et al. Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology. 2005;112:1734–46. - PMC - PubMed
    1. Ko TH, Fujimot JG, Schuman JS, et al. Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology. Ophthalmology. 2005;112:1922. - PMC - PubMed