Comment
doi: 10.1016/j.chom.2009.11.009.
Hepatitis C and evasion of the interferon system: a PKR paradigm
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- PMID: 20006836
- DOI: 10.1016/j.chom.2009.11.009
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Comment
Hepatitis C and evasion of the interferon system: a PKR paradigm
Cell Host Microbe.
.
Free article
Abstract
Hepatitis C virus (HCV) is resistant to the antiviral cytokine type I interferon, representing a major clinical problem. Garaigorta and Chisari (2009) reveal that HCV uses the activation of the ds-RNA-dependent protein kinase R, which phosphorylates and inhibits the translation initiation factor eIF-2 alpha, to block translation of interferon-stimulated genes.
Comment on
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Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation.Cell Host Microbe. 2009 Dec 17;6(6):513-22. doi: 10.1016/j.chom.2009.11.004. Cell Host Microbe. 2009. PMID: 20006840 Free PMC article.
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