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Comment
. 2009 Dec 17;6(6):495-7.
doi: 10.1016/j.chom.2009.11.009.

Hepatitis C and evasion of the interferon system: a PKR paradigm

Mariano Esteban  1
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Hepatitis C and evasion of the interferon system: a PKR paradigm

Mariano Esteban. Cell Host Microbe. .
Free article

Abstract

Hepatitis C virus (HCV) is resistant to the antiviral cytokine type I interferon, representing a major clinical problem. Garaigorta and Chisari (2009) reveal that HCV uses the activation of the ds-RNA-dependent protein kinase R, which phosphorylates and inhibits the translation initiation factor eIF-2 alpha, to block translation of interferon-stimulated genes.

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