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Randomized Controlled Trial
. 2009 Dec:65 Suppl 1:S43-6.
doi: 10.1016/j.maturitas.2009.11.013. Epub 2009 Dec 14.

Dydrogesterone support in threatened miscarriage

Mazen Y El-Zibdeh  1 , Lama T Yousef
Affiliations
Randomized Controlled Trial

Dydrogesterone support in threatened miscarriage

Mazen Y El-Zibdeh et al. Maturitas. 2009 Dec.

Abstract

Introduction: The aim of this study was to determine whether dydrogesterone helps to preserve pregnancy in women with threatened miscarriage.

Methods: 146 women who presented with mild or moderate vaginal bleeding during the first trimester of pregnancy were randomised to receive oral dydrogesterone (10mg b.i.d.) (n=86) or no treatment (n=60). Dydrogesterone was continued until 1 week after the bleeding had stopped. All women received standard supportive care.

Results: The incidence of miscarriage was significantly lower in the dydrogesterone group than in the untreated group (17.5% vs. 25%; p<0.05). There were no statistically significant differences between the groups with respect to pregnancy complications or congenital abnormalities.

Conclusion: Dydrogesterone appears to have beneficial effects in women with threatened miscarriage.

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