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Multicenter Study
. 2010 Feb;5(2):173-81.
doi: 10.2215/CJN.03170509. Epub 2009 Dec 10.

Prevalence of atrial fibrillation and its predictors in nondialysis patients with chronic kidney disease

Wanwarat Ananthapanyasut  1 , Sirikarn Napan, Earl H Rudolph, Tasma Harindhanavudhi, Husam Ayash, Kelly E Guglielmi, Edgar V Lerma
Affiliations
Multicenter Study

Prevalence of atrial fibrillation and its predictors in nondialysis patients with chronic kidney disease

Wanwarat Ananthapanyasut et al. Clin J Am Soc Nephrol. 2010 Feb.

Abstract

Background and objectives: Chronic kidney disease (CKD) increases systemic inflammation, which is implicated in development and maintenance of atrial fibrillation (AF); therefore, we hypothesized that the prevalence of AF would be increased among nondialysis patients with CKD. This study also reports independent predictors of the presence of AF in this population.

Design, setting, participants, & measurements: A retrospective, cross-sectional analysis of 1010 consecutive nondialysis patients with CKD from two community-based hospitals was conducted. Estimated GFRs (eGFRs) were calculated using the Modification of Diet in Renal Disease (MDRD) equation. Multivariate logistic regression was used to determine independent predictors.

Results: Of 1010 nondialysis patients with CKD, 214 (21.2%) had AF. Patients with AF were older than patients without AF (76 +/- 11 versus 63 +/- 15 yr). The prevalence of AF among white patients (42.7%) was higher than among black patients (12.7%) or other races (5.7%). In multivariate analyses, age, white race, increasing left atrial diameter, lower systolic BP, and congestive heart failure were identified as independent predictors of the presence of AF. Although serum high-sensitivity C-reactive protein levels were elevated in our population (5.2 +/- 7.4 mg/L), levels did not correlate with the presence of AF or with eGFR. Finally, eGFR did not correlate with the presence of AF in our population.

Conclusions: The prevalence of AF was increased in our population, and independent predictors were age, white race, increasing left atrial diameter, lower systolic BP, and congestive heart failure.

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Figures

Figure 1.
Figure 1.
Prevalence of atrial fibrillation among nondialysis patients with CKD stratified by age and race.
Figure 2.
Figure 2.
eGFR does not correlate with hsCRP levels in nondialysis patients with CKD. The correlation coefficient is R = −0.36, P = 0.757.
See this image and copyright information in PMC

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