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Editorial
. 2010 Feb;55(2):228-30.
doi: 10.1161/HYPERTENSIONAHA.109.144477. Epub 2009 Dec 14.

Angiotensin II, oxidant signaling, and hypertension: down to a T?

Robin L Davisson, Matthew C Zimmerman
Editorial

Angiotensin II, oxidant signaling, and hypertension: down to a T?

Robin L Davisson et al. Hypertension. 2010 Feb.
No abstract available

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Figures

Figure 1
Figure 1. Schematic of how the SFO may link central and peripheral mechanisms of Ang-II-dependent hypertension through activation of peripheral T cells
Perturbations in SOD (CuZnSOD, MnSOD or ecSOD) and/or AngII-mediated activation of NADPH oxidase in the SFO leads to increased oxidant formation and stimulation of downstream sympathoexcitatory circuits. Increased sympathetic nerve firing and/or circulating Ang-II may activate peripheral T cells and expression of homing signals in the vasculature and the kidney. This could promote infiltration of T lymphocytes and oxidant stress-mediated effects on vascular and renal tissues, leading to hypertension. Activated circulating T cells may also act back at the SFO to further promote this cycle.
See this image and copyright information in PMC

Comment on

References

    1. Buggy J, Fink GD, Johnson AK, Brody MJ. Prevention of the development of renal hypertension by anteroventral third ventricular tissue lesions. Circ Res. 1977;40:I110–I117. - PubMed
    1. Johnson AK, Gross PM. Sensory circumventricular organs and brain homeostatic pathways. FASEB J. 1993;7:678–686. - PubMed
    1. Lob HE, Marvar PJ, Guzik TJ, Sharma S, McCann LA, Weyand C, Gordon FJ, Harrison DG. Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system. Hypertension. 2009 XXX:XXX. - PMC - PubMed
    1. Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res. 2002;91:1038–1045. - PubMed
    1. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res. 2004;95:210–216. - PubMed

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