Review
doi: 10.4161/auto.6.1.10626.
Epub 2010 Jan 13.
PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration
Affiliations
- PMID: 20009544
- PMCID: PMC2859463
- DOI: 10.4161/auto.6.1.10626
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Review
PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration
Autophagy.
2010 Jan.
No abstract available
Figures
The Fig4 mouse mutant “pale tremor” exhibits diluted pigmentation, spongiform degeneration of the brain, and accumulation of autophagy intermediates in neurons and astrocytes. Left, wild-type littermate above, mutant below. Middle, cerebral cortex overlying hippocampal region of mutant brain. Right, accumulation of autophagy substrate p62 (red) in neurons (green, nuclear NeuN) and astrocytes (blue, GFAP); pink, colocalization of p62 and GFAP in astrocytes. (Representative examples of previously described phenotypes).
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