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Review

. 2010 Jan;6(1):170-1.

doi: 10.4161/auto.6.1.10626. Epub 2010 Jan 13.

PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration

Cole J Ferguson¹, Guy M Lenk, Miriam H Meisler

Affiliations

PMID: 20009544
PMCID: PMC2859463
DOI: 10.4161/auto.6.1.10626

Review

PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration

Cole J Ferguson et al. Autophagy. 2010 Jan.

. 2010 Jan;6(1):170-1.

doi: 10.4161/auto.6.1.10626. Epub 2010 Jan 13.

Authors

Cole J Ferguson¹, Guy M Lenk, Miriam H Meisler

Affiliation

¹ Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.

PMID: 20009544
PMCID: PMC2859463
DOI: 10.4161/auto.6.1.10626

No abstract available

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Figures

Figure 1
The Fig4 mouse mutant “pale tremor” exhibits diluted pigmentation, spongiform degeneration of the brain, and accumulation of autophagy intermediates in neurons and astrocytes. Left, wild-type littermate above, mutant below. Middle, cerebral cortex overlying hippocampal region of mutant brain. Right, accumulation of autophagy substrate p62 (red) in neurons (green, nuclear NeuN) and astrocytes (blue, GFAP); pink, colocalization of p62 and GFAP in astrocytes. (Representative examples of previously described phenotypes).

See this image and copyright information in PMC

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