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Review
. 2010 Jan;6(1):170-1.
doi: 10.4161/auto.6.1.10626. Epub 2010 Jan 13.

PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration

Cole J Ferguson  1 , Guy M Lenk, Miriam H Meisler
Affiliations
Review

PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration

Cole J Ferguson et al. Autophagy. 2010 Jan.
No abstract available

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Figures

Figure 1
Figure 1
The Fig4 mouse mutant “pale tremor” exhibits diluted pigmentation, spongiform degeneration of the brain, and accumulation of autophagy intermediates in neurons and astrocytes. Left, wild-type littermate above, mutant below. Middle, cerebral cortex overlying hippocampal region of mutant brain. Right, accumulation of autophagy substrate p62 (red) in neurons (green, nuclear NeuN) and astrocytes (blue, GFAP); pink, colocalization of p62 and GFAP in astrocytes. (Representative examples of previously described phenotypes).
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