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. 2010 Jan;13(1):19-21.
doi: 10.1038/nn.2461. Epub 2009 Dec 13.

A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse

Iancu Bucurenciu  1 , Josef Bischofberger, Peter Jonas
Affiliations

A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse

Iancu Bucurenciu et al. Nat Neurosci. 2010 Jan.

Abstract

To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered transmitter release. Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening.

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