Hepatitis C and liver transplantation
- PMID: 20011084
- PMCID: PMC2776333
Hepatitis C and liver transplantation
Abstract
Cirrhosis due to chronic hepatitis C is the leading indication for liver transplantation in Europe, United States and Japan. Reinfection after liver transplantation is universal and chronic liver disease develops in at least 70% of patients at 3 years, with an accelerated course compared to the nontransplant setting. These facts underscore the need for a better understanding of hepatitis C infection and the various treatment modalities. This paper attempts a brief review of the scope of the disease, as well as the different treatment modalities, with special emphasis given to orthotopic liver transplantation.
Keywords: hepatitis C virus; hepatocellular carcinoma; orthotopic liver transplantation.
References
-
- Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244:359–362. - PubMed
-
- Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;25(5):558–567. - PubMed
-
- WHO Hepatitis C-global prevalence (update) Wkly Epidemiol Rec. 1999;74:425–427. - PubMed
-
- Thorburn D, Roy K, Wilson K, et al. Anonymous study of hepatitis C virus (HCV) prevalence in liver transplant surgeons. Liver Transpl. 2006;12:1084–1088. - PubMed
-
- Gogos CA, Fouka KP, Nikiforidis G, et al. Prevalence of hepatitis B and C virus infection in the general population and selected groups in South-Western Greece. Eur J Epidemiol. 2003;18:551–557. - PubMed
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