Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Nov 26;5(7):758-62.
doi: 10.7150/ijbs.5.758.

Physiological and oncogenic Aurora-A pathway

Toshiaki Saeki  1 , Mutsuko Ouchi, Toru Ouchi
Affiliations
Review

Physiological and oncogenic Aurora-A pathway

Toshiaki Saeki et al. Int J Biol Sci. .

Abstract

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

Keywords: Aurora-A; Cell Cycle; Checkpoint; Genome Instability; Phosphorylation; Plk1; mTOR.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Model of Aurora-A cell transformation. Physiological regulation of Aurora-A kinase activity is by BRCA1, hBora, Ajuba, TPX2 an dPlk1 etc, however, cell transformation by Aurora-A requires additional oncogenic events, such as constitutive activation of mTOR/Akt pathway and loss of PTEN tumor suppressor .
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Glover G.M. et al.Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell. 1995;81:95–105. - PubMed
    1. Kimura M. et al.Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast lpl1. J. Bio. Chem. 1997;272:13766–13771. - PubMed
    1. Tanaka M. et al.Cell-cycle-dependent regulation of human Aurora A transcription is mediated by periodic repression of E4TF1. J. Biol. Chem. 2002;277:10719–10726. - PubMed
    1. Kimura M. et al.Cell-cycle-dependent regulation of the human Aurora B promoter. Biochem. Biophys. Res. Commun. 2004;316:930–936. - PubMed
    1. Fu J. et al.Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res. 2007;5:1–10. - PubMed

Publication types