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Review
. 2009 Nov 26;5(7):758-62.
doi: 10.7150/ijbs.5.758.

Physiological and oncogenic Aurora-A pathway

Toshiaki Saeki  1 , Mutsuko Ouchi, Toru Ouchi
Affiliations
Review

Physiological and oncogenic Aurora-A pathway

Toshiaki Saeki et al. Int J Biol Sci. .

Abstract

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

Keywords: Aurora-A; Cell Cycle; Checkpoint; Genome Instability; Phosphorylation; Plk1; mTOR.

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Conflict of interest statement

Conflict of Interest: The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Model of Aurora-A cell transformation. Physiological regulation of Aurora-A kinase activity is by BRCA1, hBora, Ajuba, TPX2 an dPlk1 etc, however, cell transformation by Aurora-A requires additional oncogenic events, such as constitutive activation of mTOR/Akt pathway and loss of PTEN tumor suppressor .
See this image and copyright information in PMC

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