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. 1991;116(1-4):133-41.
doi: 10.1007/BF01319237.

The plus strand is discontinuous in a subpopulation of unintegrated HIV-1 DNA

O Hungnes  1 , E Tjotta, B Grinde
Affiliations

The plus strand is discontinuous in a subpopulation of unintegrated HIV-1 DNA

O Hungnes et al. Arch Virol. 1991.

Abstract

During reverse transcription the synthesis of plus strand viral DNA is initiated from an RNA polypurine primer immediately upstream of the U 3 region. The polypurine tract (PPT) sequence at this site is in HIV-1 also present in the middle of the genome. Here we demonstrate that a subpopulation of linear unintegrated HIV-1 DNA has a discontinuity in the plus strand within less than 50 bp from this central PPT, consistent with its utilization as a plus strand initiation site.

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