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. 2009 Nov;35(11):1075-83.
doi: 10.1590/s1806-37132009001100004.

Prevalence of obstructive sleep apnea in children and adolescents with sickle cell anemia

[Article in English, Portuguese]
Cristina Salles  1 , Regina Terse Trindade Ramos, Carla Daltro, Andréa Barral, Jamocyr Moura Marinho, Marcos Almeida Matos
Affiliations
Free article

Prevalence of obstructive sleep apnea in children and adolescents with sickle cell anemia

[Article in English, Portuguese]
Cristina Salles et al. J Bras Pneumol. 2009 Nov.
Free article

Abstract

Objective: To estimate the prevalence of obstructive sleep apnea syndrome (OSAS) in children and adolescents with sickle cell anemia (SCA); to investigate the possible correlation between mean annual hemoglobin level and total sleep time with SpO2 < 90%, as well as between mean annual hemoglobin level and total sleep time with SpO2 < 80%; and to investigate the possible correlation between apnea-hypopnea index (AHI) and painful crisis.

Methods: The study involved 85 patients with SCA. The patients completed a questionnaire, were submitted to polysomnography and underwent clinical evaluation (by a pediatrician and an otolaryngologist). An AHI > 1 was considered indicative of a diagnosis of OSAS.

Results: The prevalence of OSAS was 10.6%. We found a negative correlation between mean annual hemoglobin level and total sleep time with SpO2 < 90% (r = micro0.343; p = 0.002), as well as between mean annual hemoglobin level and total sleep time with SpO2 < 80% (r = micro0.270; p = 0.016). There was no association between AHI and painful crisis.

Conclusions: The prevalence of OSAS in this population was high (10.6%). Therefore, it is important to identify signs of OSAS as soon as possible and to determine the mean annual hemoglobin level because of the inverse correlation between that level and the total sleep time with SpO2 < 90% or < 80%.

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