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. 2009 Jul;127(4):216-22.
doi: 10.1590/s1516-31802009000400007.

Association between osteoporosis and rheumatoid arthritis in women: a cross-sectional study

Karin Sedó Sarkis  1 , Mariana Barbieri Salvador, Marcelo Medeiros Pinheiro, Raissa Gomes Silva, Cristiano Augusto Zerbini, Lígia Araújo Martini
Affiliations

Association between osteoporosis and rheumatoid arthritis in women: a cross-sectional study

Karin Sedó Sarkis et al. Sao Paulo Med J. 2009 Jul.

Abstract
in English, Portuguese

Context and objectives: Osteoporosis has frequently been observed in patients with rheumatoid arthritis. The present study was undertaken in order to evaluate factors associated with osteoporosis among women with rheumatoid arthritis.

Design and setting: Cross-sectional study, carried out in a public hospital in São Paulo.

Methods: The participants were 83 women with rheumatoid arthritis (53.7 +/- 10.0 years old). Bone mineral density (BMD) and body composition were measured by dual energy X-ray absorptiometry. The patients were divided into three groups according to BMD: group 1, normal BMD (n = 24); group 2, osteopenia (n = 38); and group 3, osteoporosis (n = 21). Tests were performed to compare differences in means and correlations, with adjustments for age, duration of disease and cumulative corticosteroid. The relationships between clinical factors, physical activity score, dietary intake, body composition and biochemical parameters were analyzed using linear regression models.

Results: Mean calcium, vitamin D and omega-6 intakes were lower than the recommendations. Associations were found between BMD and age, disease duration, parathyroid hormone concentration and fat intake. The linear regression model showed that being older, with more years of disease and lower weight were negatively correlated with BMD [Total femur = 0.552 + 0.06 (weight) + 0.019 (total physical activity) - 0.05 (age) - 0.003 (disease duration); R(2) = 48.1; P < 0.001].

Conclusion: The present study indicates that nutritional factors and body composition are associated with bone mass in women with rheumatoid arthritis.

CONTEXTO E OBJETIVO:: A osteoporose é frequentemente observada em pacientes com artrite reumatoide (AR). O presente estudo foi realizado com o objetivo de avaliar fatores associados a osteoporose em mulheres com AR.

TIPO DE ESTUDO E LOCAL:: Estudo transversal realizado em um hospital público em São Paulo.

MÉTODOS:: Participaram 83 mulheres com AR (53.7 ± 10.0 anos). A densidade mineral óssea (DMO) e composição corporal foram mensuradas pelo método de densitômetro de dupla emissão com fonte de raios-X. Houve a divisão em grupos conforme a DMO: grupo 1 DMO normal (n = 24); grupo 2 osteopenia (n = 38) e grupo 3 osteoporose (n = 21). Foram realizados testes para comparar diferenças de médias e correlações ajustadas para idade, duração da doença e corticosteroide acumulado. A relação entre fatores clínicos, escore de atividade física, consumo alimentar, composição corporal e parâmetros bioquímicos foram analisados pelo modelo de regressão linear.

RESULTADOS:: A média de consumo de cálcio, vitamina D e ômega-6 esteve abaixo do recomendado. Houve associação entre DMO e idade, duração da doença, hormônio da paratireóide (PTH) e consumo de gordura. O modelo de regressão linear evidenciou que ser mais velho, apresentar mais anos de doença e menor peso correlacionam-se negativamente com a DMO. [Fêmur total = 0.552 + 0.06 (peso) + 0.019 (atividade física total) - 0.05 (idade) - 0.003 (duração da doença), R2 = 48.1; P < 0.001].

CONCLUSÃO:: O presente estudo indica que fatores nutricionais e de composição corporal estão associados com a massa óssea em mulheres com AR.

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Conflict of interest statement

Conflict of interest: None

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