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Comparative Study
. 2011 Apr;35(4):475-81.
doi: 10.1007/s00264-009-0915-x. Epub 2009 Dec 9.

Free vascularised fibular grafting with OsteoSet®2 demineralised bone matrix versus autograft for large osteonecrotic lesions of the femoral head

Yong Feng  1 , Shanzhi Wang, Dongxu Jin, Jiagen Sheng, Shengbao Chen, Xiangguo Cheng, Changqing Zhang
Affiliations
Comparative Study

Free vascularised fibular grafting with OsteoSet®2 demineralised bone matrix versus autograft for large osteonecrotic lesions of the femoral head

Yong Feng et al. Int Orthop. 2011 Apr.

Abstract

The aim of this study was to compare the safety and efficacy of OsteoSet®2 DBM with autologous cancellous bone in free vascularised fibular grafting for the treatment of large osteonecrotic lesions of the femoral head. Twenty-four patients (30 hips) with large osteonecrotic lesions of the femoral head (stage IIC in six hips, stage IIIC in 14, and stage IVC in ten, according to the classification system of Steinberg et al.) underwent free vascularised fibular grafting with OsteoSet®2 DBM. This group was retrospectively matched to a group of 24 patients (30 hips) who underwent free vascularised fibular grafting with autologous cancellous bone during the same time period according to the aetiology, stage, and size of the lesion and the mean preoperative Harris hip score. A prospective case-controlled study was then performed with a mean follow-up duration of 26 months. The results show no statistically significant differences between the two groups in overall clinical outcome or the radiographic assessment. Furthermore, no adverse events related to the use of the OsteoSet®2 DBM were observed. The results demonstrate that OsteoSet®2 DBM combined with autograft bone performs equally as well as that of autologous bone alone. Therefore, OsteoSet®2 DBM can be used as a safe and effective graft extender in free vascularised fibular grafting for large osteonecrotic lesions of the femoral head.

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Figures

Fig. 1
Fig. 1
a Preoperative anteroposterior radiograph of the left hip in a symptomatic 27-year-old woman with systemic lupus erythematosus (SLE) shows Steinberg stage IIIC lesion in the demineralised bone matrix (DBM) group. b Preoperative frog-leg lateral radiograph of the left hip. c Preoperative MRI of the left hip. d One-year follow-up anteroposterior radiograph of the same hip after free vascularised fibular grafting (FVFG) with OsteoSet®2 DBM. e Two-year follow-up anteroposterior radiograph. f Three-year follow-up anteroposterior radiograph shows stability of the articular cartilage and femoral head
See this image and copyright information in PMC

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