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Review
. 2009:339:85-102.
doi: 10.1007/978-3-642-02175-6_5.

The roles of tetraspanins in HIV-1 replication

Markus Thali  1
Affiliations
Review

The roles of tetraspanins in HIV-1 replication

Markus Thali. Curr Top Microbiol Immunol. 2009.

Abstract

Tetraspanins are small integral membrane proteins that are known to control a variety of cellular processes, including signaling, migration and cell-cell fusion. Research over the past few years established that they are also regulators of various steps in the HIV-1 replication cycle, but the mechanisms through which these proteins either enhance or repress virus spread remain largely unknown.

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Figures

Fig. 1
Fig. 1
Tetraspanin functions before, during and after transmission of HIV-1 particles. (A) Formation of viral exit gateways. (B) Incorporation into virions and reduction of infectivity. (C) Repression of Env-mediated virus-cell and cell-cell fusion through interactions with the receptor/coreceptor complex. (D) Reduction of susceptibility to HIV-1 infection through interference with CXCR4 transport to the cell surface. (E) Costimulation of HIV-1 gene expression. (F) Prevention of syncytia formation through interactions with Env in producer cells (see text for details)
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