Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;44(3):250-66.
doi: 10.1007/s12033-009-9230-4.

Mutational dynamics of microsatellites

Affiliations
Review

Mutational dynamics of microsatellites

Atul Bhargava et al. Mol Biotechnol. 2010 Mar.

Abstract

Microsatellites are a ubiquitous class of simple repetitive DNA sequences, which are widespread in both eukaryotic and prokaryotic genomes. The use of microsatellites as polymorphic DNA markers has considerably increased both in the number of studies and in the number of organisms, primarily for genetic mapping, studying genomic instability in cancer, population genetics, forensics, conservation biology, molecular anthropology and in the studies of human evolutionary history. Although simple sequence repeats have been extensively used in studies encompassing varied areas of genetics, the mutation dynamics of these genome regions is still not well understood. The present review focuses on the mutational dynamics of microsatellite DNA with special reference to mutational mechanisms and their role in microsatellite evolution.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biol Chem. 2000 Dec 22;275(51):40003-13 - PubMed
    1. Mol Biol Evol. 1999 May;16(5):602-10 - PubMed
    1. Nat Genet. 2002 Feb;30(2):194-200 - PubMed
    1. Mol Cell Biol. 2000 Jan;20(1):173-80 - PubMed
    1. Proc Biol Sci. 1999 Apr 22;266(1421):825-33 - PubMed

Substances

LinkOut - more resources