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Comparative Study
. 2010 May;27(5):425-9.
doi: 10.1055/s-0029-1243371. Epub 2009 Dec 11.

Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus

Lakshmi I Katakam  1 , C Michael Cotten, Ronald N Goldberg, Chi N Dang, P Brian Smith
Affiliations
Comparative Study

Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus

Lakshmi I Katakam et al. Am J Perinatol. 2010 May.

Abstract

We compared the rates of medical closure of patent ductus arteriosus (PDA) and complications (renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and intraventricular hemorrhage) between infants treated with indomethacin and infants treated with ibuprofen. We performed a retrospective comparative cohort study of infants treated with indomethacin or ibuprofen for symptomatic PDA at Duke University Medical Center between November 2005 and November 2007. We identified 65 infants who received indomethacin and 57 who received ibuprofen. The rate of survival without surgical ductal ligation was 62% (40/65) in the indomethacin group and 58% (33/57) in the ibuprofen group (p = 0.71). The rate of the composite of complications (death, necrotizing enterocolitis, or intestinal perforation) was 40% (26/65) in the indomethacin group and 32% (18/57) in the ibuprofen group (p = 0.35). There was no significant difference between groups in elevation of serum creatinine during treatment. In clinical practice, ibuprofen appears to be as effective as indomethacin for closure of patent ductus arteriosus with similar complication rates. The decision to use one agent over the other should be based on dose schedule preference and the currently published clinical trials until more safety and effectiveness data are available.

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References

    1. Poon G. Ibuprofen lysine (NeoProfen) for the treatment of patent ductus arteriosus. Proc (Bayl Univ Med Cent) 2007;20(1):83–85. - PMC - PubMed
    1. Aranda JV, Clyman R, Cox B, Van Overmeire B, Wozniak P, Sosenko I, et al. A randomized, double-blind, placebo-controlled trial on intravenous ibuprofen L-lysine for the early closure of nonsymptomatic patent ductus arteriosus within 72 hours of birth in extremely low-birth-weight infants. Am J Perinatol. 2009;26(3):235–245. - PubMed
    1. Aranda JV, Thomas R. Systematic review: intravenous Ibuprofen in preterm newborns. Semin Perinatol. 2006;30(3):114–120. - PubMed
    1. Gimeno Navarro A, Cano Sanchez A, Fernandez Gilino C, Carrasco Moreno JI, Izquierdo Macian I, Gutierrez Laso A, et al. Ibuprofen versus indomethacin in the treatment of patent ductus arteriosus in preterm infants. An Pediatr (Barc) 2005;63(3):212–218. - PubMed
    1. Lago P, Bettiol T, Salvadori S, Pitassi I, Vianello A, Chiandetti L, et al. Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: a randomised controlled trial. Eur J Pediatr. 2002;161(4):202–207. - PubMed

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