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. 2009;15(4):328-32.
doi: 10.1002/ddrr.76.

Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY

Jeannie Visootsak  1 , John M Graham Jr
Affiliations

Social function in multiple X and Y chromosome disorders: XXY, XYY, XXYY, XXXY

Jeannie Visootsak et al. Dev Disabil Res Rev. 2009.

Abstract

Klinefelter syndrome (47,XXY) was initially described in the context of its endocrinologic and physical features; however, subsequent studies have revealed specific impairments in verbal skills and social functioning. Males with sex chromosomal aneuploidies are known to have variability in their developmental profile with the majority presenting with expressive language deficits. As a consequence of language delays, they have an increased likelihood of language-based learning disabilities and social-emotional problems that may persist through adulthood. Studies on males with 47,XXY have revealed unique behavioral and social profiles with possible vulnerability to autistic traits. The prevalence of males with more than one extra sex chromosome (e.g., 48,XXYY and 48,XXXY) and an additional Y (e.g., 47,XYY) is less common, but it is important to understand their social functioning as it provides insight into treatment implications.

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References

    1. Abramsky L, Chapple J. 47,XXY (Klinefelter syndrome) and 47,XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn. 1997;17(4):363–368. - PubMed
    1. Bancroft J, Axworthy D, Ratcliffe S. The personality and psycho-sexual development of boys with 47 XXY chromosome constitution. J Child Psychol Psychiatry. 1982;23(2):169–180. - PubMed
    1. Borgaonkar DS, Mules E. Comments on patients with sex chromosome aneuploidy: dermatoglyphs, parental ages, Xg a blood group. J Med Genet. 1970;7(4):345–350. - PMC - PubMed
    1. DeLisi LE, Friedrich U, Wahlstrom J, et al. Schizophrenia and sex chromosome anomalies. Schizophr Bull. 1994;20(3):495–505. - PubMed
    1. Fryns JP, Kleczkowska A, Kubien E, et al. XYY syndrome and other Y chromosome polysomies. Mental status and psychosocial functioning. Genet Couns. 1995;6(3):197–206. - PubMed

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