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. 2009 Dec 21;15(47):5976-82.
doi: 10.3748/wjg.15.5976.

Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma

Wei-Feng Shen  1 , Wei Zhong, Feng Xu, Tong Kan, Li Geng, Feng Xie, Cheng-Jun Sui, Jia-Mei Yang
Affiliations

Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma

Wei-Feng Shen et al. World J Gastroenterol. .

Abstract

Aim: To understand the clinicopathological characteristics and treatment selections and improve survival and provide valuable information for patients with intrahepatic cholangiocarcinoma (ICC).

Methods: We retrospectively evaluated 5311 liver cancer patients who received resection between October 1999 and December 2003. Of these, 429 (8.1%) patients were diagnosed with ICC, and their clinicopathological, surgical, and survival characteristics were analyzed.

Results: Upper abdominal discomfort or pain (65.0%), no symptoms (12.1%), and hypodynamia (8.2%) were the major causes for medical attention. Laboratory tests showed 198 (46.4%) patients were HBsAg positive, 90 (21.3%) had alpha-fetoprotein > 20 microg/L, 50 (11.9%) carcinoembryonic antigen > 10 microg/L, and 242 (57.5%) carbohydrate antigen 19-9 (CA19-9) > 37 U/mL. Survival data was available for 329 (76.7%) patients and their mean survival time was 12.4 mo. The overall survival of the patients with R0, R1 resection and punching exploration were 18.3, 6.6 and 5.6 mo, respectively. Additionally, CA19-9 > 37 U/mL was associated with lymph node metastases, but inversely associated with cirrhosis. Multivariate analysis indicated that radical resection, lymph node metastases, macroscopic tumor thrombi and size, and CA19-9 were associated with prognosis.

Conclusion: Surgical radical resection is still the most effective means to cure ICC. Certain laboratory tests (such as CA19-9) can effectively predict the survival of the patients with ICC.

Keywords: Diagnosis; Intrahepatic cholangiocarcinoma; Pathology; Surgery; Survival.

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Figures

Figure 1
Figure 1
The overall survival of patients with intrahepatic cholangiocarcinoma (ICC) after surgery.
See this image and copyright information in PMC

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