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. 2010 Jan 15;12(2):368-71.
doi: 10.1021/ol902703k.

Electron transfer photoredox catalysis: intramolecular radical addition to indoles and pyrroles

Joseph W Tucker  1 , Jagan M R Narayanam, Scott W Krabbe, Corey R J Stephenson
Affiliations

Electron transfer photoredox catalysis: intramolecular radical addition to indoles and pyrroles

Joseph W Tucker et al. Org Lett. .

Abstract

The utilization of the photoredox catalyst, tris(2,2'-bipyridyl)ruthenium dichloride, and a household light bulb to effect radical cyclizations onto indoles and pyrroles at room temperature is reported. A reactive free radical intermediate is generated via the reduction of an activated C-Br bond by the single electron reductant, Ru(I), generated in a visible light induced photocatalytic cycle. This system represents an expansion of the application of photoredox catalysis in conventional free radical processes.

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