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. 2010 May;210(1):320-5.
doi: 10.1016/j.atherosclerosis.2009.11.023. Epub 2009 Nov 22.

The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study

Benjamin D Parker  1 , Leon J Schurgers, Cees Vermeer, Nelson B Schiller, Mary A Whooley, Joachim H Ix
Affiliations

The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study

Benjamin D Parker et al. Atherosclerosis. 2010 May.

Abstract

Objective: Mitral annular calcification (MAC) and aortic stenosis (AS) are associated with systemic calcification and cardiovascular disease (CVD) events. Matrix Gla protein (MGP) is an inhibitor of vascular calcification and lower levels of its precursor - uncarboxylated MGP (ucMGP) - are associated with vascular calcification in pilot studies.

Methods and results: In this cross-sectional study of 839 outpatients with stable CVD, we measured serum ucMGP, and evaluated MAC and AS by echocardiography. The association of ucMGP with MAC differed by diabetes status (interaction P<0.001). Among participants without diabetes (n=615), higher ucMGP (per standard deviation [1178nM] increase) was associated with lower odds of MAC (odds ratio [OR] 0.73; 95% confidence interval [CI] 0.55-0.97) in models adjusted for traditional CVD risk factors, C-reactive protein, and kidney function. Among persons with diabetes (n=221), higher ucMGP was associated with higher odds of MAC (OR 1.89; 95% CI 1.29-2.78). Results were qualitatively similar for the association of ucMGP with AS although not statistically significant.

Conclusions: Among outpatients with stable CVD, higher ucMGP is associated with lower odds of MAC in persons without diabetes, and higher odds of MAC in persons with diabetes. Future studies should determine whether ucMGP levels are associated with CVD events, and whether such associations differ by diabetes status.

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Conflict of interest statement

Disclosures: None.

Figures

Figure 1
Figure 1
Odds of Mitral Annular Calcification According to Diabetic Status and Tertile of Uncarboxylated Matrix Gla Protein* *Adjusted for age, sex, race, body mass index, hypertension, smoking, systolic blood pressure, diastolic blood pressure, albumin, total cholesterol, high density lipoprotein cholesterol, C-reactive protein, estimated glomerular filtration rate; Tertile 1 <2757 nM; Tertile 2757-3648 nM; Tertile 3 >3648 nM; error bars represent 95% confidence intervals
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