Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2010 Feb;24(2):355-70.
doi: 10.1038/leu.2009.261. Epub 2009 Dec 17.

Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group

W L Salzer  1 , M Devidas, W L Carroll, N Winick, J Pullen, S P Hunger, B A Camitta
Affiliations
Clinical Trial

Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children's oncology group

W L Salzer et al. Leukemia. 2010 Feb.

Abstract

From 1984 to 2001, the Pediatric Oncology Group (POG) conducted 12 acute lymphoblastic leukemia (ALL) studies. Ten-year event-free survival (EFS) for patients >12 months of age with B-precursor ALL on acute leukemia in children 14, 15 and 16 series were 66.7+/-1.2%, 68.1+/-1.4% and 73.2+/-2.1%, respectively. Intermediate dose methotrexate (ID MTX; 1 g/m(2)) improved outcomes for standard risk patients (10-year EFS 77.5+/-2.7% vs 66.3+/-3.1% for oral MTX). Neither MTX intensification (2.5 g/m(2)) nor addition of cytosine arabinoside/daunomycin/teniposide improved outcomes for higher risk patients. Intermediate dose mercaptopurine (1 g/m(2)) failed to improve outcomes for either group. Ten-year EFS for patients with T-cell ALL, POG 8704 and 9404 were 49.1+/-3.1% and 72.2+/-4.7%, respectively. Intensive asparaginase (10-year EFS 61.8 vs 42.7%) and high-dose MTX (5 g/m(2)) (10-year EFS 78.0 vs 65.8%) improved outcomes. There was a non-significant improvement in EFS for infants (10-year EFS 17.7+/-7.2-31.9+/-8.3%). Prognostic indicators for B-precursor ALL were age and WBC at diagnosis, gender, central nervous system disease, DNA index and cytogenetic abnormalities. Only gender was prognostic in T-cell ALL. In infants, WBC and MLL translocation were linked to inferior outcome.

PubMed Disclaimer

Figures

Figure 1
Figure 1
B-Precursor ALL (A) Event-Free Survival by Era, (B) Overall Survival by Era, (C) ALinC 14: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) ALinC 15: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (E) ALinC 16: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 1
Figure 1
B-Precursor ALL (A) Event-Free Survival by Era, (B) Overall Survival by Era, (C) ALinC 14: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) ALinC 15: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (E) ALinC 16: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 1
Figure 1
B-Precursor ALL (A) Event-Free Survival by Era, (B) Overall Survival by Era, (C) ALinC 14: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) ALinC 15: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (E) ALinC 16: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 1
Figure 1
B-Precursor ALL (A) Event-Free Survival by Era, (B) Overall Survival by Era, (C) ALinC 14: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) ALinC 15: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (E) ALinC 16: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 1
Figure 1
B-Precursor ALL (A) Event-Free Survival by Era, (B) Overall Survival by Era, (C) ALinC 14: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) ALinC 15: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (E) ALinC 16: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 2
Figure 2
T-Cell ALL (A) Event-Free Survival by Study, (B) Overall Survival by Study, (C) POG 8704: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) POG 9404: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 2
Figure 2
T-Cell ALL (A) Event-Free Survival by Study, (B) Overall Survival by Study, (C) POG 8704: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) POG 9404: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 2
Figure 2
T-Cell ALL (A) Event-Free Survival by Study, (B) Overall Survival by Study, (C) POG 8704: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) POG 9404: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 2
Figure 2
T-Cell ALL (A) Event-Free Survival by Study, (B) Overall Survival by Study, (C) POG 8704: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death, (D) POG 9404: Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 3
Figure 3
Infant ALL (A) EFS and Overall Survival, (B) Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
Figure 3
Figure 3
Infant ALL (A) EFS and Overall Survival, (B) Cumulative Incidence Rates of all CNS relapse, isolated CNS relapse, SMN, and death
See this image and copyright information in PMC

References

    1. Fast Stats: An interactive tool for access to SEER cancer statistics. Surveillance Research Program, National Cancer Institute; [Accessed on 8-25-2009]. http://seer.cancer.gov/faststats.
    1. Pulte D, Gondos A, Brenner H. Trends in 5- and 10-year Survival After Diagnosis with Childhood Hematologic Malignancies in the United States, 1990-2004. J Natl Cancer Inst. 2008 Sep 17;100(18):1301–1309. 2008. - PubMed
    1. Hunger S, Devidas M, Camitta B, Gaynon P, Winick N, Reaman G, et al. Improved Survival For Children With Acute Lymphoblastic Leukemia (ALL) From 1990–2005: A Report From The Childrens Oncology Group (COG) Wiley-Liss, Inc; Berlin, Germany: 2008. p. 31. SIOP 3-6 Oct. - PMC - PubMed
    1. Harris MB, Shuster JJ, Pullen DJ, Borowitz MJ, Carroll AJ, Behm FG, et al. Consolidation therapy with antimetabolite-based therapy in standard-risk acute lymphocytic leukemia of childhood: a Pediatric Oncology Group Study. J Clin Oncol. 1998;16(8):2840–2847. - PubMed
    1. Harris MB, Shuster JJ, Pullen J, Borowitz MJ, Carroll AJ, Behm FG, et al. Treatment of children with early pre-B and pre-B acute lymphocytic leukemia with antimetabolite-based intensification regimens: a Pediatric Oncology Group Study. Leukemia. 2000 Sep;14(9):1570–1576. - PubMed

Publication types

MeSH terms