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. 2009 Summer;3(2):108-13.
doi: 10.4162/nrp.2009.3.2.108. Epub 2009 Jun 30.

Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet

Mi-Ja Choi  1
Affiliations

Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet

Mi-Ja Choi. Nutr Res Pract. 2009 Summer.

Abstract

Taurine supplementation has been shown to have a beneficial effect on femur bone mineral content in ovariectomized rats. It therefore seemed desirable to find out whether the beneficial effect of taurine on ovariectomized rats fed calcium deficient diet could also be reproduced. Forty female Sprague-Dawley rats were divided into two groups. One group was OVX and the other group received sham operation (SHAM), and received either control diet or a taurine supplemented diet for 6 weeks. All rats were fed on calcium deficient diet (AIN-93: 50% level of calcium) and deionized water. Bone mineral density (BMD) and bone mineral content (BMC) were measured in spine and femur. The serum and urine concentrations of calcium and phosphorus were determined. Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations. Bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Urinary calcium and phosphorus excretion, osteocalcin in blood and cross link value were not significantly different among the groups. Within the OVX group, the taurine supplemented group had not higher femur bone mineral content than the control group. This study established the need for a study on the taurine effect on bone with different calcium levels.

Keywords: BMD; OVX; Taurine; calcium deficient diet.

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References

    1. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. 1985;76:370–373. - PMC - PubMed
    1. Boujendar S, Reusens B, Merezak S, Ahn MT, Arany E, Hill D, Remacle C. Taurine supplementation to a low protein diet during fetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia. 2002;45:856–866. - PubMed
    1. Broadus AE. Physiological functions of calcium, magnesium, and phosphorus and mineral ion balance. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. New York. USA: Raven Press; 1993. pp. C 41–C 46.
    1. Choi MJ. Effects of dietary taurine supplementation on plasma and liver lipids in Ovx rats fed calcium-deficient diet. Nutrition Research and Practice. 2008;2:13–16. - PMC - PubMed
    1. Choi MJ, DiMarco NM. The effects of dietary taurine supplementation on bone mineral density in ovariectmized rats. Adv Exp Med Biol. 2009;643:341–349. - PubMed