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. 2009:2009:186136.
doi: 10.1155/2009/186136. Epub 2009 Nov 16.

Protection of Salvia miltiorrhizae to the spleen and thymus of rats with severe acute pancreatitis or obstructive jaundice

Zhang Xiping  1 , Li Chuyang, Zhang Jie, Ruan Yuefang, Ma Meili
Affiliations

Protection of Salvia miltiorrhizae to the spleen and thymus of rats with severe acute pancreatitis or obstructive jaundice

Zhang Xiping et al. Mediators Inflamm. 2009.

Abstract

Objective: To investigate the therapeutic effects and mechanism of Salvia miltiorrhizae in the treatment of SAP and OJ.

Methods: A total of 288 rats were used for SAP- and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group and treated group. The mortality rates of rats, contents of endotoxin and PLA(2) in blood, pathological changes of different indexes in spleen and thymus were observed.

Results: The contents of endotoxin and PLA2 in treated group were significantly lower than those in model control group.The pathological severity scores of spleen and thymus of SAP rats as well as that of spleen of OJ rats in treated groups were significantly lower than those in model control groups (P < .05). The staining intensity as well as the product of the staining intensity and positive rate of Bax protein of spleen in model control group were significantly higher than those in treated groups (P < .01) , and the apoptosis index of spleen in treated group was significantly lower than that in model control group (P < .01).

Conclusion: Salvia miltiorrhizae exerts protective effects on the spleen and thymus of SAP rats and spleen of OJ rats.

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Figures

Figure 1
Figure 1
Model control group—6 hours in SAP experiment spleen (several apoptoic cells), TUNEL × 400.
Figure 2
Figure 2
Treated group—6 hours in SAP experiment spleen (several apoptoic cells) TUNEL, × 400.
Figure 3
Figure 3
Sham-operated group—12 hours in SAP experiment thymus (normal), Electron microscope × 2550.
Figure 4
Figure 4
Model control group—12 hours in SAP experiment thymus (apoptoic cells obviously increase in thymus), Electron microscope × 1850.
Figure 5
Figure 5
Treated group—12 hours in SAP experiment thymus (normal thymic lymphocyte and reticulate epithelium) Electron microscope × 5000.
Figure 6
Figure 6
Model control group—28 days in OJ experiment spleen (several apoptoic cells), TUNEL × 400.
Figure 7
Figure 7
Treated group—28 days in OJ experiment spleen (several apoptoic cells), TUNEL × 400.
Figure 8
Figure 8
Model control group—21 d in OJ experiment (++) spleen, Bax × 200.
Figure 9
Figure 9
Treated group—21 d in OJ experiment (+) spleen, Bax × 200.
Figure 10
Figure 10
Sham-operated group—28 d in OJ experiment thymus (negative TUNEL × 200).
Figure 11
Figure 11
Model control group—28 d in OJ experiment thymus (many apoptoic cells), TUNEL × 400.
Figure 12
Figure 12
Treated group—28 d in OJ experiment thymus (several apoptoic cells), TUNEL × 400.
Figure 13
Figure 13
Model control group—7 d in OJ experiment thymus (+++), Bax × 200.
Figure 14
Figure 14
Model control group—21 d in OJ experiment thymus (++), Bax × 200.
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