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Review
. 2009 Dec;52(12):1117-22.
doi: 10.1007/s11427-009-0158-5. Epub 2009 Dec 17.

Circulating miRNA and cancer diagnosis

Yi Tie  1 , BinDong Liu, HanJiang Fu, XiaoFei Zheng
Affiliations
Review

Circulating miRNA and cancer diagnosis

Yi Tie et al. Sci China C Life Sci. 2009 Dec.

Abstract

miRNAs are a class of small RNA molecules with regulatory function, and play an important role in tumor development and progression. It has been demonstrated that tumor-derived miRNAs exist in the circulating nucleic acids of cancer patients. This phenomenon implies that detection of the circulating miRNA may be an effective method for non-invasive diagnosis of cancer. In this review, we summarize the applications of the circulating miRNA as biomarkers in cancer diagnosis, as well as the latest research progress in this area.

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