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Review
. 2010 Feb;52(1):207-17.
doi: 10.1111/j.1600-0757.2009.00322.x.

Cellular and bacterial profiles associated with oral epithelium-microbiota interactions

Jeffrey J Mans, Erik L Hendrickson, Murray Hackett, Richard J Lamont
Review

Cellular and bacterial profiles associated with oral epithelium-microbiota interactions

Jeffrey J Mans et al. Periodontol 2000. 2010 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1. HIGK Cell Cycle Transcriptional Response to Aggregatibacter actinomycetemcomitans
BRB Array Tools was used to generate probesets differentially regulated at the P<0.05 level of significance. The geometric mean signal intensity level for probesets passing this threshold were analyzed with Pathway Express software to populate known KEGG pathways according to transcriptional profiles obtained from GeneChip experiments. Nodes shown in red are transcriptionally induced in HIGK cells encountering wild-type A. actinomycetemcomitans compared to uninfected cells. Nodes shown in blue are transcriptionally repressed. Nodes in green are unchanged at the P<0.05 significance level.
Fig. 2
Fig. 2. Metabolic Map of Energy and Cytotoxin Production
Proteins catalyzing each step are shown by their Porphyromonas. gingivalis PGN (strain 33277) designation. Red up arrows indicate increased levels upon internalization, green down arrows decreased levels, and yellow squares no statistical change. Acetyl-CoA appears as a substrate and product at multiple points and is shown in purple. Metabolites and metabolic precursors discussed in the text are shown in bold. Reprinted from BMC Microbiology, 2009, in press.
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