Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Apr;49(2):186-99.
doi: 10.1016/j.plipres.2009.12.002. Epub 2009 Dec 16.

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

Hervé Guillou  1 , Damir Zadravec, Pascal G P Martin, Anders Jacobsson
Affiliations
Review

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

Hervé Guillou et al. Prog Lipid Res. 2010 Apr.

Abstract

In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the past decade, a great deal has been learnt about these enzymes and the first part of this review summarizes our current knowledge concerning these enzymes. More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.

PubMed Disclaimer

Publication types

LinkOut - more resources