Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Dec 1;96(456):1410-1423.
doi: 10.1198/016214501753382327.

Marginal Mean Models for Dynamic Regimes

S A Murphy, M J van der Laan, J M Robins; CPPRG

Marginal Mean Models for Dynamic Regimes

S A Murphy et al. J Am Stat Assoc. .

Abstract

A dynamic treatment regime is a list of rules for how the level of treatment will be tailored through time to an individual's changing severity. In general, individuals who receive the highest level of treatment are the individuals with the greatest severity and need for treatment. Thus there is planned selection of the treatment dose. In addition to the planned selection mandated by the treatment rules, the use of staff judgment results in unplanned selection of the treatment level. Given observational longitudinal data or data in which there is unplanned selection, of the treatment level, the methodology proposed here allows the estimation of a mean response to a dynamic treatment regime under the assumption of sequential randomization.

PubMed Disclaimer

References

    1. Aitchison J, Silvey SD. Maximum-Likelihood Estimation of Parameters Subject to Restraints. Ann. Math. Statist. 1958;29:813–828.
    1. Angrist JD, Imbens GW, Rubin DB. Identification of causal effects using instrumental variables. Journal of the American Statistical Association. 1996;91:434–471.
    1. Bickel P, Klaassen C, Ritov Y, Wellner J. Efficient and adaptive estimation for semiparametric models. Baltimore: Johns Hopkins University Press; 1993.
    1. Bierman KL, Greenberg MT . The Conduct Problems Prevention Research Group. Social skill training in the FAST Track program. In: Peters R DeV, McMahon RJ., editors. Preventing childhood disorders, substance abuse, and delinquency. Newbury Park, CA: Sage; 1996. pp. 65–89.
    1. Borhani NO, Applegate WB, Cutler JA, Davis BR, Furberg CD, Lakatos E, Page L, Perry HM, Smith WM, Probstfield JL. Part 1: Rationale and Design. Hypertension. 1991;17 suppl II:II-2–II-15. - PubMed

Publication types

LinkOut - more resources