Maternal blood lead levels and the risk of pregnancy-induced hypertension: the EDEN cohort study

Abstract

Background: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure.

Objective: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy.

Methods: One thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l' Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation.

Results: PIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean +/- SD, 2.2 +/- 1.4 microg/dL) than in normotensive patients (1.9 +/- 1.2 microg/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1-9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation.

Conclusions: These findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH.

Keywords: cadmium; environmental health; epidemiology; gestation; hypertension; lead; manganese.

Figure 1

Scatterplot of the residuals for maternal blood lead and SBP between 24 and 36 weeks (P2) after controlling for the effect of variables listed in the logistic model in Table 3: correlation between residuals of the linear regression of the two variables on the partialed variables. In the 95% and 70% prediction ellipses, the major axis length is significantly larger than the minor axis length, indicating a partial correlation between maternal blood lead and SBP at P2.