Review
doi: 10.1016/j.ceb.2009.11.011.
Transmitting the message: intracellular mRNA localization
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- PMID: 20022233
- DOI: 10.1016/j.ceb.2009.11.011
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Review
Transmitting the message: intracellular mRNA localization
Curr Opin Cell Biol.
2010 Feb.
Abstract
The intracellular localization of mRNA is an important mechanism for targeting proteins to their sites of function. Localized transcripts play key roles ranging from body axis determination to synapse plasticity, and recent studies highlight how common localized transcripts are in a variety of model organisms. In this review, we consider the full range of known mechanisms for delivering transcripts and anchoring them at their site of function. Finally, we evaluate the progress that has been made in the nervous system in understanding the mechanism and function of mRNA localization and translation regulation.
Copyright 2009 Elsevier Ltd. All rights reserved.
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