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Randomized Controlled Trial
. 2010 Mar;202(3):263.e1-5.
doi: 10.1016/j.ajog.2009.10.859. Epub 2009 Dec 22.

The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

Jason N Hashima  1 , Yinglei Lai, Ronald J Wapner, Yoram Sorokin, Donald J Dudley, Alan Peaceman, Catherine Y Spong, Jay D Iams, Kenneth J Leveno, Margaret Harper, Steve N Caritis, Michael Varner, Menachem Miodovnik, Brian M Mercer, John M Thorp, Mary J O'Sullivan, Susan M Ramin, Marshall Carpenter, Dwight J Rouse, Baha Sibai; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
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Randomized Controlled Trial

The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

Jason N Hashima et al. Am J Obstet Gynecol. 2010 Mar.

Abstract

Objective: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids.

Study design: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and > or = 25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome.

Results: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of > or = 25. The composite outcome occurred more frequently in the body mass index of > or = 2 5 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding.

Conclusion: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

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Figures

Figure 1
Figure 1
The proportion of women with the composite primary outcome by BMI category
See this image and copyright information in PMC

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