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. 2010 Jan;133(1):102-6.
doi: 10.1309/AJCPXLZPRHX9L0YG.

Frequency of bacille Calmette-Guerin (BCG) and Mycobacterium tuberculosis in tissue biopsy specimens of children vaccinated with BCG

Maryam Monajemzadeh  1 , Reza Shahsiah, Abdolmajid Zarei, Alireza Alai Alamooti, Fatemeh Mahjoub, Setareh Mamishi, Ghamartaj Khotai, Reza Pazira, Neda Eram
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Frequency of bacille Calmette-Guerin (BCG) and Mycobacterium tuberculosis in tissue biopsy specimens of children vaccinated with BCG

Maryam Monajemzadeh et al. Am J Clin Pathol. 2010 Jan.

Abstract

Vaccination of all newborns with bacille Calmette-Guérin (BCG) vaccine is a standard practice in developing countries. Disseminated mycobacterial infection in an immunocompromised child can be caused by BCG and other mycobacteria. A total of 21 patients with a histopathologic diagnosis of mycobacterial infection were studied in a period of 4 years. DNA was extracted from formalin-fixed, paraffin-embedded tissues. Real-time polymerase chain reaction was performed to determine the mycobacterial species. The overall sensitivity of the assay was 71.5%. The prevalence rates of BCG, Mycobacterium tuberculosis, and other mycobacteria in the positive results were 80% (12/15), 13% (2/15), and 7% (1/15), respectively.

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