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. 2010 Jan;42(1):24-6.
doi: 10.1038/ng.506. Epub 2009 Dec 20.

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

Elisabeth Mangold  1 , Kerstin U Ludwig, Stefanie Birnbaum, Carlotta Baluardo, Melissa Ferrian, Stefan Herms, Heiko Reutter, Nilma Almeida de Assis, Taofik Al Chawa, Manuel Mattheisen, Michael Steffens, Sandra Barth, Nadine Kluck, Anna Paul, Jessica Becker, Carola Lauster, Gül Schmidt, Bert Braumann, Martin Scheer, Rudolf H Reich, Alexander Hemprich, Simone Pötzsch, Bettina Blaumeiser, Susanne Moebus, Michael Krawczak, Stefan Schreiber, Thomas Meitinger, Hans-Erich Wichmann, Regine P Steegers-Theunissen, Franz-Josef Kramer, Sven Cichon, Peter Propping, Thomas F Wienker, Michael Knapp, Michele Rubini, Peter A Mossey, Per Hoffmann, Markus M Nöthen
Affiliations

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate

Elisabeth Mangold et al. Nat Genet. 2010 Jan.

Abstract

We conducted a genome-wide association study for nonsyndromic cleft lip with or without cleft palate (NSCL/P) in 401 affected individuals and 1,323 controls, with replication in an independent sample of 793 NSCL/P triads. We report two new loci associated with NSCL/P at 17q22 (rs227731, combined P = 1.07 x 10(-8), relative risk in homozygotes = 1.84, 95% CI 1.34-2.53) and 10q25.3 (rs7078160, combined P = 1.92 x 10(-8), relative risk in homozygotes = 2.17, 95% CI 1.32-3.56).

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References

    1. Dev Dyn. 2007 Jul;236(7):1918-28 - PubMed
    1. Hum Genet. 1979 Apr 27;48(2):241-4 - PubMed
    1. Mech Dev. 2007 Sep-Oct;124(9-10):746-61 - PubMed
    1. Am J Hum Genet. 2009 Mar;84(3):406-11 - PubMed
    1. Nat Genet. 2009 Apr;41(4):473-7 - PubMed

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