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. 2010 Jan 14;46(2):261-3.
doi: 10.1039/b921237j. Epub 2009 Nov 24.

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Ian Paterson  1 , Guy J Naylor, Takeshi Fujita, Esther Guzmán, Amy E Wright
Affiliations

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Ian Paterson et al. Chem Commun (Camb). .

Abstract

A hybrid library of the marine natural products dictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.

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