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Comparative Study
. 1991 Mar 5;218(1):13-7.
doi: 10.1016/0022-2836(91)90867-6.

A large number of tRNA genes are symmetrically located in fission yeast centromeres

K Takahashi  1 , S Murakami, Y Chikashige, O Niwa, M Yanagida
Affiliations
Comparative Study

A large number of tRNA genes are symmetrically located in fission yeast centromeres

K Takahashi et al. J Mol Biol. .

Abstract

We report here that the fission yeast centromere regions in the three chromosomes contain no less than 36 symmetrically arranged tRNA-coding sequences, and many of them are located within the inner inverted regions that are thought to be essential for the centromere function. There are 11 different species of tRNA-coding sequences, and four of them are identical to those previously known in this organism. This high-density distribution of tRNA genes in the centromere regions is surprising, as the fission yeast centromeres were thought to form transcriptionally inactive structures.

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