Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar;53(3):217-23.
doi: 10.1002/ajim.20788.

Occupational factors and risk of Parkinson's disease: A population-based case-control study

Jordan A Firestone  1 , Jessica I Lundin, Karen M Powers, Terri Smith-Weller, Gary M Franklin, Phillip D Swanson, W T Longstreth Jr, Harvey Checkoway
Affiliations

Occupational factors and risk of Parkinson's disease: A population-based case-control study

Jordan A Firestone et al. Am J Ind Med. 2010 Mar.

Abstract

Background: Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent.

Objective: To estimate the risk of PD associated with various jobs and workplace exposures.

Methods: We conducted a population-based, case-control study of 404 incident PD cases and 526 age and sex-matched controls, collecting self-reported work histories including job titles and exposures to various industrial toxicants. Relative risks of PD from these exposures were estimated with odds ratios (OR) and 95% confidence intervals (CI) using logistic regression.

Results: Risk was not significantly affected by farming work, by metal work, or by exposure to pesticides, metals, or solvents.

Conclusions: These findings do not provide support for the hypothesis that workplace factors affect the risk of PD.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest.

References

    1. Arima H, Sobue K, So M, Morishima T, Ando H, Katsuya H. Transient and reversible parkinsonism after acute organophosphate poisoning. J Toxicol Clin Toxicol. 2003;41:67–70. - PubMed
    1. Ascherio A, Chen H, Weisskopf MG, O’Reilly E, McCullough ML, Calle EE, Schwarzschild MA, Thun MJ. Pesticide exposure and risk for Parkinson’s disease. Ann Neurol. 2006;60:197–203. - PubMed
    1. Baldi I, Lebailly P, Mohammed-Brahim B, Letenneur L, Dartigues JF, Brochard P. Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol. 2003;157:409–414. - PubMed
    1. Barcia C, Fernandez Barreiro A, Poza M, Herrero MT. Parkinson’s disease and inflammatory changes. Neurotox Res. 2003;5:411–418. - PubMed
    1. Bhatt MH, Elias MA, Mankodi AK. Acute and reversible parkinsonism due to organophosphate pesticide intoxication: Five cases. Neurology. 1999;52:1467–1471. - PubMed

Publication types

MeSH terms