Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 Jan 15;201(2):171-4.
doi: 10.1086/649427.

Double-edged genetic swords and immunity: lesson from CCR5 and beyond

Editorial

Double-edged genetic swords and immunity: lesson from CCR5 and beyond

Sunil K Ahuja et al. J Infect Dis. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The yin-yang of infectious disease alleles. The concept of yin and yang illustrates the detrimental (black region) and beneficial (white region) effects of different infectious disease-influencing alleles in the human genome. Illustrated are the CCR5Δ32 allele, Duffy antigen receptor for chemokines (DARC)-null allele (FYO), and the sickle cell allele (HbS). HIV, human immunodeficiency virus; WNV, West Nile virus.

Comment on

References

    1. Lederberg J. JBS Haldane (1949) on infectious disease and evolution. Genetics. 1999;153:1–3. - PMC - PubMed
    1. Lim JK, McDermott DH, Lisco A, et al. CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection, but not for viral transmission. J Infect Dis. 2010;201:178–85. (in this issue) - PMC - PubMed
    1. Stiehm ER. Disease versus disease: how one disease may ameliorate another. Pediatrics. 2006;117:184–191. - PubMed
    1. Mayr FB, Spiel AO, Leitner JM, et al. Duffy antigen modifies the chemokine response in human endotoxemia. Crit Care Med. 2008;36:159–165. - PubMed
    1. Mayr FB, Spiel AO, Leitner JM, et al. Racial differences in endotoxin-induced tissue factor-triggered coagulation. J Thromb Haemost. 2009;7:634–640. - PubMed

Substances