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. 1991 Apr;65(4):2131-4.
doi: 10.1128/JVI.65.4.2131-2134.1991.

Minimal Rev-response element for type 1 human immunodeficiency virus

X J Huang  1 , T J Hope, B L Bond, D McDonald, K Grahl, T G Parslow
Affiliations

Minimal Rev-response element for type 1 human immunodeficiency virus

X J Huang et al. J Virol. 1991 Apr.

Abstract

Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.

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References

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