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Review
. 2010 Jul 8;323(1):70-5.
doi: 10.1016/j.mce.2009.12.009. Epub 2009 Dec 16.

Gut endocrine cell development

Catherine Lee May  1 , Klaus H Kaestner
Affiliations
Review

Gut endocrine cell development

Catherine Lee May et al. Mol Cell Endocrinol. .
No abstract available

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Figures

Figure 1
Figure 1
Illustration of the major cell types found in the gastrointestinal epithelium. Gastric epithelium contains mucus, chief, Parietal, and endocrine cells, whereas enterocyte, goblet, endocrine, and Paneth cells are found in the intestinal epithelium. Intestinal stem cells are depicted in red in the diagram. Chromogranin A staining marks all enteroendocrine cells in the gastrointestinal epithelium.
Figure 2
Figure 2
Involvement of the Notch signaling pathway during endocrine cell differentiation. The Notch ligand Delta is first up-regulated in differentiating endocrine cells. It binds to Notch on neighboring non-endocrine cells, which results in release of the Notch intracellular domain (Notch IC). Notch IC translocates into the nucleus and interacts with RBP-Jκ to activate target genes such as Hes1. Hes1 then inhibits proendocrine bHLH transcription factors such as Ngn3.
Figure 3
Figure 3
Overview of enteroendocrine cell differentiation in the intestinal epithelium. Stem cells marked by Lgr5 are located in the crypt and give rise to all four cell types found in the intestinal epithelium. Expression of Math1/Hes1 restricts secretory lineages (Paneth, goblet and endocrine cells) from the absorptive lineage (enterocyte). Once this initial specification is established, lineage-specific transcription factors such as Sox9 for Paneth cells, Klf4 for goblet cells and Gfi1/Ngn3/NeuroD for enteroendocrine cells are required for the proper differentiation of their respective secretory lineages.
See this image and copyright information in PMC

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