Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Feb;55(2):445-52.
doi: 10.1161/HYPERTENSIONAHA.109.145839. Epub 2009 Dec 21.

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

Carlos M Ferrario  1
Affiliations
Review

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

Carlos M Ferrario. Hypertension. 2010 Feb.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Data (Means ± SEM), redrawn from Nagata et al (77), illustrate the relative concentrations of angiotensin-(1–12) [Ang-(1–12)], angiotensin I [Ang I], and angiotensin II [Ang II] in tissues and plasma from the Japanese-derived strain of normotensive Wistar rats.
Figure 2
Figure 2
Representative micrographs of angiotensin-(1–12) immunostaining from cardiac (A) and renal (B) tissue of WKY and SHR (upper images in each panel). In panel A, faint immunostaining for Ang-(1–12) is observed in the myocardium of WKY while intense punctuate staining is expressed in left ventricular myocytes of SHR. Panel B illustrates the expression of Ang-(1–12) immunostaining in sections of kidney cortex from WKY and SHR. Fluorescent staining for Ang-(1–12) found in renal tubules is increased in sections obtained from SHR. Nuclei are indicated by 4′,6-diamidino-2-phenylindole (DAPI) blue fluorescence staining. Lower images in each panel illustrate merged confocal and phase contrast immunostaining for each organ. From studies reported in our reference. (80)
Figure 3
Figure 3
Panels A to C are peak concentrations of angiotensin peptides resulting from the addition of 10 nmol Ang-(1–12) to the perfusate of isolated hearts from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) adult rats. Panel D illustrated renin concentration in the effluent of isolated perfused hearts from WKY and SHR. Before, peak angiotensin values obtained 60 min after administration of Ang-(1–12); After, shows the absence of a change in the peak values of Ang-(1–12) following administration of 1 μmol/L of the rat specific renin inhibitor WFML-1. Data (Means ± SEM) redrawn from our reference. (81)
Figure 4
Figure 4
Plasma and cardiac tissue concentrations of angiotensin peptides in sham and 48 h bilateral nephrectomized (BNX) rats reveals differential expression of angiotensin-(1–12) [Ang-(1–12)], angiotensin I (Ang I) and angiotensin II (Ang II) in adult Wistar Kyoto rats. Data redrawn from our reference (82)
Figure 5
Figure 5
Diagram of the biochemical pathways leading to the formation of angiotensin peptides in tissues. Abbreviations are: ACE, angiotensin converting enzyme; ACE2, angiotensin converting enzyme 2; NEP, neutral endopeptidase 24.11 and related endopeptidases contributing to formation of Ang-(1–7) from Ang I. (12)
See this image and copyright information in PMC

References

    1. Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz DI. Counterregulatory actions of angiotensin-(1–7) Hypertension. 1997;30:535–541. - PubMed
    1. Gavras H, Brunner HR, Laragh JH, Gavras I, Vukovich RA. The use of angiotensin-converting enzyme inhibitor in the diagnosis and treatment of hypertension. Clin Sci Mol Med Suppl. 1975;2:57s–60s. - PubMed
    1. Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD. Discovery of losartan, the first angiotensin II receptor antagonist. J Hum Hypertens. 1995;9 (Suppl 5):S3–18. - PubMed
    1. Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1–7) heptapeptide. Proc Natl Acad Sci U S A. 1988;85(11):4095–4098. - PMC - PubMed
    1. Benter IF, Diz DI, Ferrario CM. Cardiovascular actions of angiotensin(1–7) Peptides. 1993;14:679–684. - PubMed

Publication types