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Review
. 2010 Feb;55(2):445-52.
doi: 10.1161/HYPERTENSIONAHA.109.145839. Epub 2009 Dec 21.

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

Carlos M Ferrario  1
Affiliations
Review

New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism

Carlos M Ferrario. Hypertension. 2010 Feb.
No abstract available

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Conflict of interest statement

Conflict of Interest

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Data (Means ± SEM), redrawn from Nagata et al (77), illustrate the relative concentrations of angiotensin-(1–12) [Ang-(1–12)], angiotensin I [Ang I], and angiotensin II [Ang II] in tissues and plasma from the Japanese-derived strain of normotensive Wistar rats.
Figure 2
Figure 2
Representative micrographs of angiotensin-(1–12) immunostaining from cardiac (A) and renal (B) tissue of WKY and SHR (upper images in each panel). In panel A, faint immunostaining for Ang-(1–12) is observed in the myocardium of WKY while intense punctuate staining is expressed in left ventricular myocytes of SHR. Panel B illustrates the expression of Ang-(1–12) immunostaining in sections of kidney cortex from WKY and SHR. Fluorescent staining for Ang-(1–12) found in renal tubules is increased in sections obtained from SHR. Nuclei are indicated by 4′,6-diamidino-2-phenylindole (DAPI) blue fluorescence staining. Lower images in each panel illustrate merged confocal and phase contrast immunostaining for each organ. From studies reported in our reference. (80)
Figure 3
Figure 3
Panels A to C are peak concentrations of angiotensin peptides resulting from the addition of 10 nmol Ang-(1–12) to the perfusate of isolated hearts from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) adult rats. Panel D illustrated renin concentration in the effluent of isolated perfused hearts from WKY and SHR. Before, peak angiotensin values obtained 60 min after administration of Ang-(1–12); After, shows the absence of a change in the peak values of Ang-(1–12) following administration of 1 μmol/L of the rat specific renin inhibitor WFML-1. Data (Means ± SEM) redrawn from our reference. (81)
Figure 4
Figure 4
Plasma and cardiac tissue concentrations of angiotensin peptides in sham and 48 h bilateral nephrectomized (BNX) rats reveals differential expression of angiotensin-(1–12) [Ang-(1–12)], angiotensin I (Ang I) and angiotensin II (Ang II) in adult Wistar Kyoto rats. Data redrawn from our reference (82)
Figure 5
Figure 5
Diagram of the biochemical pathways leading to the formation of angiotensin peptides in tissues. Abbreviations are: ACE, angiotensin converting enzyme; ACE2, angiotensin converting enzyme 2; NEP, neutral endopeptidase 24.11 and related endopeptidases contributing to formation of Ang-(1–7) from Ang I. (12)
See this image and copyright information in PMC

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References

    1. Ferrario CM, Chappell MC, Tallant EA, Brosnihan KB, Diz DI. Counterregulatory actions of angiotensin-(1–7) Hypertension. 1997;30:535–541. - PubMed
    1. Gavras H, Brunner HR, Laragh JH, Gavras I, Vukovich RA. The use of angiotensin-converting enzyme inhibitor in the diagnosis and treatment of hypertension. Clin Sci Mol Med Suppl. 1975;2:57s–60s. - PubMed
    1. Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD. Discovery of losartan, the first angiotensin II receptor antagonist. J Hum Hypertens. 1995;9 (Suppl 5):S3–18. - PubMed
    1. Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1–7) heptapeptide. Proc Natl Acad Sci U S A. 1988;85(11):4095–4098. - PMC - PubMed
    1. Benter IF, Diz DI, Ferrario CM. Cardiovascular actions of angiotensin(1–7) Peptides. 1993;14:679–684. - PubMed

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