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Randomized Controlled Trial
. 2011 Feb;15(2):130-8.
doi: 10.1177/1087054709356165. Epub 2009 Dec 21.

Effect of atomoxetine on executive function impairments in adults with ADHD

Thomas E Brown  1 , James Holdnack, Keith Saylor, Lenard Adler, Thomas Spencer, David W Williams, Anoop K Padival, Kory Schuh, Paula T Trzepacz, Douglas Kelsey
Affiliations
Randomized Controlled Trial

Effect of atomoxetine on executive function impairments in adults with ADHD

Thomas E Brown et al. J Atten Disord. 2011 Feb.

Abstract

Objective: To assess the effect of atomoxetine on ADHD-related executive functions over a 6-month period using the Brown Attention-Deficit Disorder Scale (BADDS) for Adults, a normed, 40-item, self-report scale in a randomized, double-blind, placebo-controlled clinical trial.

Method: In a randomized, double-blind clinical trial, adults with ADHD received either atomoxetine 25 to 100 mg/day or placebo for 6 months. Patients completed the BADDS to report their current daily functioning in 5 clusters of ADHD-related impairments of executive functioning: (1) Organizing and Activating to Work; (2) Focusing for Tasks; (3) Regulating Alertness and Effort; (4) Modulating Emotions; and (5) Utilizing Working Memory.

Results: Mean scores were significantly more improved in the atomoxetine group compared to the placebo group: total score, -27.0 versus -19.0 (p < .001); all 5 cluster scores, p < .01.

Conclusions: Once-daily atomoxetine can improve executive function impairments in adults with ADHD as assessed by the BADDS.

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