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Randomized Controlled Trial
. 2010 Jan;115(1):55-59.
doi: 10.1097/AOG.0b013e3181c52132.

Metformin compared with glyburide in gestational diabetes: a randomized controlled trial

Lisa E Moore  1 , Diana Clokey, Valerie J Rappaport, Luis B Curet
Affiliations
Randomized Controlled Trial

Metformin compared with glyburide in gestational diabetes: a randomized controlled trial

Lisa E Moore et al. Obstet Gynecol. 2010 Jan.

Abstract

Objective: To compare the efficacy of metformin with glyburide for glycemic control in gestational diabetes.

Methods: Patients with gestational diabetes who did not achieve glycemic control on diet were randomly assigned to metformin (n=75) or glyburide (n=74) as single agents. The primary outcome was glycemic control. Secondary outcomes were drug failure rate and neonatal and obstetric complications.

Results: In the patients who achieved adequate glycemic control, the mean fasting and 2-hour postprandial blood glucose levels were not statistically different between the two groups. However, 26 patients in the metformin group (34.7%) and 12 patients in the glyburide group (16.2%) did not achieve adequate glycemic control and required insulin therapy (P=.01).

Conclusion: In this study, the failure rate of metformin was 2.1 times higher than the failure rate of glyburide when used in the management of gestational diabetes (95% confidence interval 1.2-3.9).

Clinical trial registration: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00965991.

Level of evidence: I.

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References

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