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. 1991 Mar;254(2):125-33.
doi: 10.1016/0921-8777(91)90003-8.

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

P A Jeggo  1 , J Tesmer, D J Chen
Affiliations

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

P A Jeggo et al. Mutat Res. 1991 Mar.

Abstract

The genetic diversity of a range of ionising radiation sensitive mutants of cultured mammalian cell lines has been examined. Hybrids were constructed from suitably marked diploid cells by cell fusion and selected using resistance to HAT and ouabain. Hybrids were examined for ploidy and gamma-ray sensitivity. The data suggest that at least 8 and possibly 9 complementation groups exist which confer sensitivity to ionising radiation. Mutants in at least 3 distinct complementation groups have a reduced ability to rejoin DNA double-strand breaks.

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