doi: 10.1111/j.1747-0285.2009.00923.x.
Epub 2009 Dec 17.
Synthesis and antileishmanial activity of lipidic amino alcohols
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- PMID: 20028395
- DOI: 10.1111/j.1747-0285.2009.00923.x
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Synthesis and antileishmanial activity of lipidic amino alcohols
Chem Biol Drug Des.
2010 Feb.
Abstract
In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC(50) below 10 microm. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.
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