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Comparative Study
. 2010 Mar;54(3):1347-50.
doi: 10.1128/AAC.01324-09. Epub 2009 Dec 22.

Comparison of anidulafungin MICs determined by the clinical and laboratory standards institute broth microdilution method (M27-A3 document) and Etest for Candida species isolates

Ana Espinel-Ingroff  1 , E Canton, J Peman, E Martín-Mazuelo
Affiliations
Comparative Study

Comparison of anidulafungin MICs determined by the clinical and laboratory standards institute broth microdilution method (M27-A3 document) and Etest for Candida species isolates

Ana Espinel-Ingroff et al. Antimicrob Agents Chemother. 2010 Mar.

Abstract

Anidulafungin Etest and CLSI MICs were compared for 143 Candida sp. isolates to assess essential (within 2 log(2) dilutions) and categorical agreements (according to three susceptibility breakpoints). Based on agreement percentages, our data indicated that Etest is not suitable to test anidulafungin against Candida parapsilosis and C. guilliermondii (54.4 to 82.4% essential and categorical agreements) but is more suitable for C. albicans, C. glabrata, C. krusei, and C. tropicalis (87.9 to 100% categorical agreement).

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Figures

FIG. 1.
FIG. 1.
Comparison of anidulafungin broth microdilution and Etest MICs for 143 Candida sp. isolates. Interpretive susceptibility MIC breakpoints (≤2 μg/ml and ≤0.5 μg/ml) are indicated by the horizontal and vertical lines, respectively (11, 21).
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References

    1. Alexander, B. D., T. C. Byrne, K. L. Smith, K. E. Hanson, K. J. Anstrom, J. R. Perfect, and L. B. Reller. 2007. Comparative evaluation of Etest and Sensititre YeastOne panels against the Clinical and Laboratory Standards Institute M27-A2 reference broth microdilution method for testing Candida susceptibility to seven antifungal agents. J. Clin. Microbiol. 45:698-706. - PMC - PubMed
    1. Arendrup, M. C., G. Garcia-Effron, W. Buzina, K. L. Mortensen, N. Reiter, C. Lundin, H. E. Jensen, C. Lass-Flörl, D. S. Perlin, and B. Bruun. 2009. Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. Antimicrob. Agents Chemother. 53:1185-1193. - PMC - PubMed
    1. Arendrup, M. C., S. Perkhofer, S. J. Howard, G. Garcia-Effron, A. Vishukumar, D. Perlin, and C. Lass-Flörl. 2008. Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins. Antimicrob. Agents Chemother. 52:3504-3511. - PMC - PubMed
    1. Baixench, M.-T., N. Aoun, M. Desnos-Ollivier, D. Garcia-Hermoso, S. Bretagne, S. Ramires, C. Piketty, and E. Dannaoui. 2007. Acquired resistance to echinocandins in Candida albicans: case report and review. J. Antimicrob. Chemother. 59:1076-1083. - PubMed
    1. Barchiesi, F., E. Spreghini, S. Tomassetti, A. Della Vittoria, D. Arzeni, E. Manso, and G. Scalise. 2006. Effects of caspofungin against Candida guilliermondii and Candida parapsilosis. Antimicrob. Agents Chemother. 50:2719-2727. - PMC - PubMed

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