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Review
. 2009 Oct;57(7):789-94.
doi: 10.2310/JIM.0b013e3181bb0d49.

Central leptin receptor action and resistance in obesity

Christian Bjørbaek  1
Affiliations
Review

Central leptin receptor action and resistance in obesity

Christian Bjørbaek. J Investig Med. 2009 Oct.

Abstract

The discovery of leptin in 1994 has led to remarkable advances in obesity research. We now know that leptin is a cytokinelike hormone that is produced in adipose tissue and plays a pivotal role in regulation of energy balance and in a variety of additional processes via actions in the central nervous system. This symposium review covers current understandings of neuronal leptin receptor signaling and mechanisms of obesity-related leptin resistance in the central nervous system and provides recent insights into the regulation of peripheral glucose balance by central leptin action in rodents.

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