Review
doi: 10.1515/BC.2010.013.
Principles, implementation, and application of biology-oriented synthesis (BIOS)
Affiliations
- PMID: 20030592
- DOI: 10.1515/BC.2010.013
Item in Clipboard
Review
Principles, implementation, and application of biology-oriented synthesis (BIOS)
Biol Chem.
2010 May.
Free article
Abstract
Biology-oriented synthesis (BIOS) represents an alternative approach for the generation of compound collections for biological applications. In BIOS, biologically relevant and prevalidated scaffold structures, such as core structures of natural products or known drugs, are employed as scaffolds for the generation of compound collections with focused diversity. In this review, we discuss the underlying concept of the BIOS approach, and its practical implementation in library design and synthesis. To highlight its relevance for chemical biology applications, we finally present examples in which compound collections generated under the BIOS principle have been used to elucidate biological questions.
Similar articles
-
Bioactivity-guided navigation of chemical space.Acc Chem Res. 2010 Aug 17;43(8):1103-14. doi: 10.1021/ar100014h. Acc Chem Res. 2010. PMID: 20481515
-
Gamma-pyrone natural products--a privileged compound class provided by nature.Bioorg Med Chem. 2009 Mar 15;17(6):2304-9. doi: 10.1016/j.bmc.2008.11.001. Epub 2008 Nov 8. Bioorg Med Chem. 2009. PMID: 19042133 Review.
-
Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC).Mol Biosyst. 2005 May;1(1):36-45. doi: 10.1039/b503623b. Epub 2005 Apr 19. Mol Biosyst. 2005. PMID: 16880961 Review.
-
Synthesis of proline-based diketopiperazine scaffolds.J Org Chem. 2009 Jun 5;74(11):4267-71. doi: 10.1021/jo9004876. J Org Chem. 2009. PMID: 19391606
-
Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).Chem Asian J. 2007 Sep 3;2(9):1109-26. doi: 10.1002/asia.200700125. Chem Asian J. 2007. PMID: 17685373
Cited by
-
Traceless Solid-Phase Synthesis of Ketones via Acid-Labile Enol Ethers: Application in the Synthesis of Natural Products and Derivatives.Molecules. 2019 Apr 10;24(7):1406. doi: 10.3390/molecules24071406. Molecules. 2019. PMID: 30974778 Free PMC article.
-
The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitations.Front Plant Sci. 2011 Dec 26;2:101. doi: 10.3389/fpls.2011.00101. eCollection 2011. Front Plant Sci. 2011. PMID: 22639623 Free PMC article.
-
The evolving biology of small molecules: controlling cell fate and identity.Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2208-21. doi: 10.1098/rstb.2011.0006. Philos Trans R Soc Lond B Biol Sci. 2011. PMID: 21727126 Free PMC article. Review.
-
Automating drug discovery.Nat Rev Drug Discov. 2018 Feb;17(2):97-113. doi: 10.1038/nrd.2017.232. Epub 2017 Dec 15. Nat Rev Drug Discov. 2018. PMID: 29242609 Review.
-
Targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches.Molecules. 2011 May 27;16(6):4408-27. doi: 10.3390/molecules16064408. Molecules. 2011. PMID: 21623312 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
