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. 2010 Jan;16(1):139-42.
doi: 10.3201/eid1601.090007.

Acute encephalopathy associated with influenza A infection in adults

Nelson Lee  1 , Chun Kwok Wong, Paul K S Chan, Niklas Lindegardh, Nicholas J White, Frederick G Hayden, Edward H C Wong, Ka Shing Wong, Clive S Cockram, Joseph J Y Sung, David S C Hui
Affiliations

Acute encephalopathy associated with influenza A infection in adults

Nelson Lee et al. Emerg Infect Dis. 2010 Jan.

Abstract

We report acute encephalopathy associated with influenza A infection in 3 adults. We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis.

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