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. 2010 May;34(5):677-81.
doi: 10.1016/j.leukres.2009.10.026. Epub 2009 Dec 23.

Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

Sophie L Corthals  1 , Mojca Jongen-Lavrencic, Yvonne de Knegt, Justine K Peeters, H Berna Beverloo, Henk M Lokhorst, Pieter Sonneveld
Affiliations

Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

Sophie L Corthals et al. Leuk Res. 2010 May.

Abstract

We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions.

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